A number of 4′-aza-2′,3′-dideoxy nucleosides have been synthesized in good yields and short reaction times by straightforward microwave assisted 1,3-cycloaddition of vinyl nucleobases with nitrones, in the absence of solvent. The vinyl nucleobases are used, for the first time, in their unprotected form.

A number of 4'-aza-2',3'-dideoxy nucleosides have been synthesized in good yields and short reaction times by straightforward microwave assisted 1,3-cycloaddition of vinyl nucleobases with nitrones, in the absence of solvent. The vinyl nucleobases are used, for the first time, in their unprotected form. (C) 2008 Elsevier Ltd. All rights reserved.

Solvent free, microwave assisted 1,3-cycloaddition of nitrones with vinyl nucleobases for the synthesis of N,O-nucleosides

DE NINO, Antonio;MAIUOLO, Loredana;SINDONA, Giovanni
2008-01-01

Abstract

A number of 4′-aza-2′,3′-dideoxy nucleosides have been synthesized in good yields and short reaction times by straightforward microwave assisted 1,3-cycloaddition of vinyl nucleobases with nitrones, in the absence of solvent. The vinyl nucleobases are used, for the first time, in their unprotected form.
2008
A number of 4'-aza-2',3'-dideoxy nucleosides have been synthesized in good yields and short reaction times by straightforward microwave assisted 1,3-cycloaddition of vinyl nucleobases with nitrones, in the absence of solvent. The vinyl nucleobases are used, for the first time, in their unprotected form. (C) 2008 Elsevier Ltd. All rights reserved.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/122668
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