A novel synthesis of gamma-lactam derivatives 4 is reported, based on PdI2-catalyzed oxidative monoaminocarbonylation of 2-ynylamines, followed by in situ conjugate addition of a secondary amine and lactamization. Tetramic acids can be easily obtained from 4 by acid-catalyzed hydrolysis at room temperature.
A new synthesis of 4-dialkylamino-1,5-dihydropyrrol-2-ones by Pd-catalyzed oxidative Aminocarbonylation of 2-Ynylamines
GABRIELE, Bartolo;PLASTINA, Pierluigi;
2005-01-01
Abstract
A novel synthesis of gamma-lactam derivatives 4 is reported, based on PdI2-catalyzed oxidative monoaminocarbonylation of 2-ynylamines, followed by in situ conjugate addition of a secondary amine and lactamization. Tetramic acids can be easily obtained from 4 by acid-catalyzed hydrolysis at room temperature.File in questo prodotto:
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