Abstract: Wendtia calycina (Griseb.) Griseb., Vivianiaceae, is a Paraguayanherbaceous plant commonly known as burrito. Our previous study indicated thatburrito leaves are a very good source of phenylpropanoid glycosides, principallyverbascoside. From W. calycina leaves, a standardized, water-soluble extract richin phenylpropanoid glycosides (WSE) has been developed on an industrial scale tobe used as a food supplement, cosmetic, phytomedicine, and ingredient of differentformulations. In this study, we investigated the effect of the WSE on human plateletaggregation in vitro induced by adenosine diphosphate (ADP), epinephrine (EPN),collagen (COL) or arachidonic acid (AA). WSE, concentration-dependently,inhibited ADP and EP-induced human platelet aggregation (IC50 were 0.82±0.15mg/mL and 0.41±0.02 mg/mL, respectively). It did not inhibit collagen-inducedplatelet aggregation, thus suggesting a selectivity for the ADP-induced plateletactivation pathways.
Inhibition of human platelet aggregation in vitro by standardized extract of Wendtia calycina
FAZIO, Alessia;
2011-01-01
Abstract
Abstract: Wendtia calycina (Griseb.) Griseb., Vivianiaceae, is a Paraguayanherbaceous plant commonly known as burrito. Our previous study indicated thatburrito leaves are a very good source of phenylpropanoid glycosides, principallyverbascoside. From W. calycina leaves, a standardized, water-soluble extract richin phenylpropanoid glycosides (WSE) has been developed on an industrial scale tobe used as a food supplement, cosmetic, phytomedicine, and ingredient of differentformulations. In this study, we investigated the effect of the WSE on human plateletaggregation in vitro induced by adenosine diphosphate (ADP), epinephrine (EPN),collagen (COL) or arachidonic acid (AA). WSE, concentration-dependently,inhibited ADP and EP-induced human platelet aggregation (IC50 were 0.82±0.15mg/mL and 0.41±0.02 mg/mL, respectively). It did not inhibit collagen-inducedplatelet aggregation, thus suggesting a selectivity for the ADP-induced plateletactivation pathways.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
