Spherical molecularly imprinted polymers (SMIPs) have been prepared via a novel precipitation polymerization using sulfasalazine (prodrug used in the diseases of the colon) as template. The sulfasalazine was incorporated into SMIPs and into a spherical non-imprinted polymer (control), and then the release rate of the bioactive agent at different pH values was evaluated. Considerable differences in the release characteristics between imprinted and nonimprinted polymers have been observed. This opens the possibility of the development of drug release systems capable of modulating the release of a specific molecule.
Spherical Molecularly Imprinted Polymers (SMIPs) via a novel precipitation Polymerization in the Controlled delivery of Sulfasalazine
Puoci F;IEMMA F;MUZZALUPO R;Spizzirri UG;TROMBINO Sonia;CASSANO R;Picci N
2004-01-01
Abstract
Spherical molecularly imprinted polymers (SMIPs) have been prepared via a novel precipitation polymerization using sulfasalazine (prodrug used in the diseases of the colon) as template. The sulfasalazine was incorporated into SMIPs and into a spherical non-imprinted polymer (control), and then the release rate of the bioactive agent at different pH values was evaluated. Considerable differences in the release characteristics between imprinted and nonimprinted polymers have been observed. This opens the possibility of the development of drug release systems capable of modulating the release of a specific molecule.File in questo prodotto:
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