Two sets of compounds derived from the fusion of a diversely annulatednaphthoxazepinedione system with 1,3-thiazole and 1,3-oxazole are described. These compounds are close analogues ofpreviously reported thiazolothiazepine inhibitors of human immunodeficiencyvirus type 1 integrase (HIV-1 IN). Some of thenew derivatives show potency similar to that of the referencecompounds, thus gaining further insight into the structure–activityrelationship of this class of IN inhibitors.
Naphthoxazepine Inhibitors of HIV-1 Integrase: Synthesis and Biological Evaluation
GAROFALO A
;GRANDE, Fedora;AIELLO, Francesca;
2008-01-01
Abstract
Two sets of compounds derived from the fusion of a diversely annulatednaphthoxazepinedione system with 1,3-thiazole and 1,3-oxazole are described. These compounds are close analogues ofpreviously reported thiazolothiazepine inhibitors of human immunodeficiencyvirus type 1 integrase (HIV-1 IN). Some of thenew derivatives show potency similar to that of the referencecompounds, thus gaining further insight into the structure–activityrelationship of this class of IN inhibitors.File in questo prodotto:
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