This study has the goal to evaluate the stability of B complex vitamins, loaded into catechin-based 22 crosslinked hydrogels, in aqueous medium at accelerated conditions of oxidative stress. The formulations 23 were prepared by coupling polyacrylic acid with catechin in the presence of dicycloexylcarbodiimide. 24 Folic acid (FA) and Thiamine (TH) were chosen within the B complex vitamins because of the well-known 25 oxidative degradation characteristics. The protective role of the hydrogels against the oxidation damage 26 was monitored inducing oxidative stress, by means of UV irradiation and t-butyl hydroperoxide treat- 27 ment for FA and TH, respectively. The characterization of the hydrogels was obtained by morphological, 28 calorimetric, FT-IR analyses, antioxidant assays and evaluation of the swelling behavior in aqueous media 29 at different pH. The experimental results confirmed the suitability of the hydrogels as pH-responsive 30 devices, furthermore the presence of oxidative condition proved the protective effect of the hydrogels. 31 Catechin-based polymers gave a pronounced improvement in the stability of vitamins compared to 32 hydrogels prepared by the coupling reaction of polyacrylic acid in the presence of 1,6-hexandiol. Under 33 oxidative conditions, FA and TH were preserved by 96% and 60% respectively.
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|Titolo:||Stabilization of oxidable vitamins by flavonoid-based hydrogels|
|Data di pubblicazione:||2013|
|Citazione:||Stabilization of oxidable vitamins by flavonoid-based hydrogels / Spizzirri, Ug; Cirillo, G; Curcio, M; Altimari, I; Picci, Nevio; Iemma, Francesca. - In: REACTIVE & FUNCTIONAL POLYMERS. - ISSN 1381-5148. - 73(2013), pp. 1030-1037.|
|Appare nelle tipologie:||1.1 Articolo in rivista|