A novel, multicomponent and stereoselective approach to functionalized indane derivatives is reported. It is based on a tandem process consisting of Pd-catalyzed oxidative carbamoylation of 2-(2-ethynylbenzyl) malonates with carbon monoxide, a secondary amine, and oxygen (with formation of a propiolamide intermediate), followed by carbocyclization, occurring through intramolecular addition of an in situ formed carbanion to the propiolamide moiety.
Cascade Reactions: A Multicomponent Approach to Functionalized Indane Derivatives by a Tandem Palladium-Catalyzed Carbamoylation/Carbocylization Process
GABRIELE, Bartolo;VELTRI, Lucia;Mancuso R;
2014-01-01
Abstract
A novel, multicomponent and stereoselective approach to functionalized indane derivatives is reported. It is based on a tandem process consisting of Pd-catalyzed oxidative carbamoylation of 2-(2-ethynylbenzyl) malonates with carbon monoxide, a secondary amine, and oxygen (with formation of a propiolamide intermediate), followed by carbocyclization, occurring through intramolecular addition of an in situ formed carbanion to the propiolamide moiety.File in questo prodotto:
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