Goal of the present study was the characterization of the biological properties of a gelatin-gallic acid conjugate (Gel-GA) to evaluate its applicability in biomedicine and pharmacy. The macromolecular conjugate was synthesized by free radical grafting reaction between gelatin and gallic acid (GA) to form a covalent conjugate that was found to retain the antioxidant and enzymatic activities of free GA. In particular, the peroxynitrite scavenging power was found to be consistent with a IC50 value of 2.17 ± 0.4 mg mL-1. The enzymatic capacities of GA, which are regarded beneficial for cell functions, are partly retained in the Gel-GA conjugate. In particular, acetylcholinesterase inhibition (IC50 of 7.1 ± 1.3 mg mL-1) implies the conjugate's usefulness in the chemoprevention of Alzheimer's disease, while the inhibition of α-amylase (IC50 of 9.8 ± 1.1 mg mL-1) suggests that the conjugate can be a preferred alternative for inhibition of carbohydrate breakdown and control of glycemic index of food products. Finally, the anticancer activity of Gel-GA was proven in prostate carcinoma and renal cell carcinoma cell lines, confirming the potential of the proposed protein-polyphenol conjugate in medicine.
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|Titolo:||The Biological Activity of a Gallic acid-Gelatin Conjugate|
|Data di pubblicazione:||2010|
|Citazione:||The Biological Activity of a Gallic acid-Gelatin Conjugate / Cirillo, G; Kraemer, K; Fuessel, S; Puoci, F; Curcio, M; Spizzirri, Ug; Altimari, I; Iemma, Francesca. - In: BIOMACROMOLECULES. - ISSN 1525-7797. - 11:12(2010), pp. 3309-3315.|
|Appare nelle tipologie:||1.1 Articolo in rivista|