PROBLEM TO BE SOLVED: To obtain a deoxynucleotide carrier regulating toxic effect of a chemotherapeutic compound and an anti-virus compound. SOLUTION: Disclosed is a mitochondoria deoxynucleotide carrier (DNC) transporting a deoxynucleoside diphosphate, (a) catalizing exchange of dATP for dADP or ADP according to the first order kinetics and rate constant of 0.02 min<-1> , (b) having optimum pH at 6.8, and (c) exchanging dATP from dNDPs more effectively than in the cases of NTPs, dNTP, dNMPs and pyrophosphate.

MITOCHONDORIA PROTEIN

DOLCE, Vincenza
2003-01-01

Abstract

PROBLEM TO BE SOLVED: To obtain a deoxynucleotide carrier regulating toxic effect of a chemotherapeutic compound and an anti-virus compound. SOLUTION: Disclosed is a mitochondoria deoxynucleotide carrier (DNC) transporting a deoxynucleoside diphosphate, (a) catalizing exchange of dATP for dADP or ADP according to the first order kinetics and rate constant of 0.02 min<-1> , (b) having optimum pH at 6.8, and (c) exchanging dATP from dNDPs more effectively than in the cases of NTPs, dNTP, dNMPs and pyrophosphate.
2003
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/177173
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact