Even though there exists commercial software (as Partek Genomic Suite) useful for analyzing data stemming from gene expression profile (by microarray technology), the need for open source solutions arises both from the direct usage and re-utilization of the software, and from the need of third-party reviews of the source code. Our research aims at developing a flowbased system that can bring to the identification of genes that can foster medical comprehension and explanation of the Multiple Sclerosis (MS) disease focusing on exon/gene level analysis combined with microRNA data analysis. The data was granted thanks to research collaboration with Sapienza University in Rome; the biological objective is to analyze the whole B lymphocyte-transcriptome (coding and non-coding RNA meaning, respectively, mRNA and microRNA) from the peripheral blood in the MS disease context.

Design and implementation of a flow-based system for the analysis of HumanExon and microRNA array chip data

CALIMERI, Francesco;
2012-01-01

Abstract

Even though there exists commercial software (as Partek Genomic Suite) useful for analyzing data stemming from gene expression profile (by microarray technology), the need for open source solutions arises both from the direct usage and re-utilization of the software, and from the need of third-party reviews of the source code. Our research aims at developing a flowbased system that can bring to the identification of genes that can foster medical comprehension and explanation of the Multiple Sclerosis (MS) disease focusing on exon/gene level analysis combined with microRNA data analysis. The data was granted thanks to research collaboration with Sapienza University in Rome; the biological objective is to analyze the whole B lymphocyte-transcriptome (coding and non-coding RNA meaning, respectively, mRNA and microRNA) from the peripheral blood in the MS disease context.
978-3-642-33756-7
immune systems; microRNA; Multiple Sclerosis
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/178775
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