The incidence of neurological disorders is constantly growing; hence, the scientific community is intensifying the efforts spent in order to design approaches capable of determining the onset of such disorders. In this paper we focus on a specific neurological disorder, namely Multiple Sclerosis, a chronic disease of the central nervous system. We propose a method for identifying specific brain substructures that might underpin a worsening disease, thus allowing to delineate a number of potentially vulnerable brain regions. The task is addressed by means of a simulation procedure which iteratively disrupt brain regions. Experimental results show that the proposed simulation produces reliable graphs with respect to the used dataset.

Inducing Clinical Course Variations in Multiple Sclerosis White Matter Networks

Aldo Marzullo;Francesco Calimeri;
2019

Abstract

The incidence of neurological disorders is constantly growing; hence, the scientific community is intensifying the efforts spent in order to design approaches capable of determining the onset of such disorders. In this paper we focus on a specific neurological disorder, namely Multiple Sclerosis, a chronic disease of the central nervous system. We propose a method for identifying specific brain substructures that might underpin a worsening disease, thus allowing to delineate a number of potentially vulnerable brain regions. The task is addressed by means of a simulation procedure which iteratively disrupt brain regions. Experimental results show that the proposed simulation produces reliable graphs with respect to the used dataset.
978-3-030-22870-5
978-3-030-22871-2
Classification
Complex network analysis
Multiple Sclerosis
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11770/315259
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact