Background and aims: neutropenia (N) is common in patients receiving chemotherapy. In literature higher incidence of G3/G4-N was reported in first chemotherapy cycle. Febrile-N (FN) is associated with significant morbidity and mortality. Retrospectively, we evaluated efficacy and safety of single injection of P (6 mg) compared with daily L (263 μg) in primary prophylaxis of N, in NMBC and chemotherapy-naïve patients receiving adjuvant FEC100. Methods: 35 women (median age 54 years) underwent 6 cycles of chemotherapy. At every cycle, 17 patients received daily L from day 5 to 9 (5 total injections), while 18 patients received one dose of P on day 2. Incidence of N, FN and bone pain (NRS >7) were evaluated. Results: in overall population incidence of N was 66%, while G3/G4-N was 54%. In P arm, N was 50%, all G3/G4-N. In L arm N was 82%, of which 58% was G3/G4-N. One case of FN occurred in P arm. During first cycle, incidence of G3/G4-N was 33% and 41% in P and L arms, respectively; no G3/G4-N occurred during the last cycle. Incidence of bone pain was 11% in both arms. Chemotherapy reduction occurred in 50% and 29% in P and L arm, respectively. Conclusions: in our experience, a single injection of P was more effective than 5 daily administration of L, in particular for G3/G4-N incidence, also during first cycle. More dose reduction was made in P arm. The safety profiles of P and L were similar with the same incidence of bone pain.
EFFICACY AND SAFETY PROFILES OF PEGFILGRASTIM (P) AND LENOGRASTIM (L) IN NON METASTATIC BREAST CANCER (NMBC) PATIENTS RECEIVING ADJUVANT FEC100
CAPALBO, CARLO;
2014-01-01
Abstract
Background and aims: neutropenia (N) is common in patients receiving chemotherapy. In literature higher incidence of G3/G4-N was reported in first chemotherapy cycle. Febrile-N (FN) is associated with significant morbidity and mortality. Retrospectively, we evaluated efficacy and safety of single injection of P (6 mg) compared with daily L (263 μg) in primary prophylaxis of N, in NMBC and chemotherapy-naïve patients receiving adjuvant FEC100. Methods: 35 women (median age 54 years) underwent 6 cycles of chemotherapy. At every cycle, 17 patients received daily L from day 5 to 9 (5 total injections), while 18 patients received one dose of P on day 2. Incidence of N, FN and bone pain (NRS >7) were evaluated. Results: in overall population incidence of N was 66%, while G3/G4-N was 54%. In P arm, N was 50%, all G3/G4-N. In L arm N was 82%, of which 58% was G3/G4-N. One case of FN occurred in P arm. During first cycle, incidence of G3/G4-N was 33% and 41% in P and L arms, respectively; no G3/G4-N occurred during the last cycle. Incidence of bone pain was 11% in both arms. Chemotherapy reduction occurred in 50% and 29% in P and L arm, respectively. Conclusions: in our experience, a single injection of P was more effective than 5 daily administration of L, in particular for G3/G4-N incidence, also during first cycle. More dose reduction was made in P arm. The safety profiles of P and L were similar with the same incidence of bone pain.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
