Optimizing pharmacological treatments among older people with chronic kidney disease (CKD) is by no means an easy task. It may be very difficult to distinguish changes in kidney function related to aging from clinically relevant CKD. Additionally, among older people, CKD is usually observed in the context of complex multimorbidity profiles which may conceal its clinical presentation and delay diagnosis. Guidelines not always provide age-specific recommendations for treating CKD and related disorders, and there is substantial evidence suggesting that target of treatments should carefully adapted to the older population. Additionally, CKD is known to increase the risk of nephrotoxicity. Taking into account patient- and drug-related factors, as well as avoiding potentially dangerous interactions and reducing inappropriate prescribing, may be useful to prevent nephrotoxicity.
Optimizing Pharmacotherapy in Older Patients: An Interdisciplinary Approach: Chronic Kidney Disease
Corsonello A.;
2023-01-01
Abstract
Optimizing pharmacological treatments among older people with chronic kidney disease (CKD) is by no means an easy task. It may be very difficult to distinguish changes in kidney function related to aging from clinically relevant CKD. Additionally, among older people, CKD is usually observed in the context of complex multimorbidity profiles which may conceal its clinical presentation and delay diagnosis. Guidelines not always provide age-specific recommendations for treating CKD and related disorders, and there is substantial evidence suggesting that target of treatments should carefully adapted to the older population. Additionally, CKD is known to increase the risk of nephrotoxicity. Taking into account patient- and drug-related factors, as well as avoiding potentially dangerous interactions and reducing inappropriate prescribing, may be useful to prevent nephrotoxicity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
