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Evaluating Quinolines: Molecular Dynamics Approach to Assess Their Potential as Acetylcholinesterase Inhibitors for Alzheimer's Disease

: Quinoline represents a promising scaffold for developing potential drugs because of the wide range of biological and pharmacological activities that it exhibits. In the present study, quinoline derivatives obtained from CADMA-Chem docking protocol were investigated in the mean of molecular dynamics simulations as potential inhibitors of acetylcholinesterase enzyme. The examined species can be partitioned between neutral, dq815 (2,3 dihydroxyl-quinoline-4-carbaldehyde), dq829 (2,3 dihydroxyl...

Targeting Cancer Metabolism as a New Strategy to Enhance Treatment Efficacy and Overcome Resistance

Oltre il Web. La pedagogia di genere per contrastare l’hate speech online contro le donne

Hate speech, a particularly widespread phenomenon especially against women, has deep cultural roots related to gender and social norms that promote the idea of male superiority. This violent and sexist language, by normalizing gender discrimination, represents a crucial challenge for the world of education, which must find effective strategies to counter its spread and promote a culture of respect and inclusion. The hypothesis of these reflections is that an education based on gender pedagogy...

Prerequisiti della lettura: valutare la consapevolezza fonologica.

Evidenze scientifiche ed insegnamento della lettura. Perché una alfabetizzazione fono-sillabica strutturata è necessaria per tutti i bambini

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