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EnglishNiosomes have shown promise as cheap and chemically stable drug delivery systems. In this paper a novel crown ether amphiphile, 1,16-hexadecanoyl-bis-(2-aminomethyl)-18-crown-6 (Bola A-16), has been synthesized with the aim of developing a long time stable controlled release system. Niosomes have been prepared with different molar ratios of amphiphile and cholesterol and their morphological properties have been determined by quasi-elastic light scattering and transmission electron microscopy. The composition of niosomes affects the entrapment efficiency and the release rate of 5-fluorouracil, a well-known antineoplastic molecule. In addition, other two known azacrown ether amphiphiles (4,710.13-pentaoxa-16-aza-cyclooctadecane)-hexadecanedioc acid diamide (Bola D-16) and alpha,omega-(4,7,10,13-pentaoxa-16-aza-cyclooctadecane)hexadecane (Bola C-16), have been synthesized and the obtained vesicles have been characterized for comparison. Furthermore, the release profile of 5-fluorouracil in vitro, from these niosomes, has been studied over a period of 6 h in order to simulate a hematic adsorption.
A new crown ether as vesicular carrier for 5-fluoruracil: Synthesis, characterization and drug delivery evaluation / Muzzalupo, Rita; NICOLETTA Fiore Pasquale, ; Trombino, Sonia; Cassano, Roberta; Iemma, Francesca; Picci, N.. - In: COLLOIDS AND SURFACES. B, BIOINTERFACES. - ISSN 0927-7765. - 58(2007), pp. 197-202.
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| Titolo: | A new crown ether as vesicular carrier for 5-fluoruracil: Synthesis, characterization and drug delivery evaluation |
| Autori: | |
| Data di pubblicazione: | 2007 |
| Rivista: | |
| Citazione: | A new crown ether as vesicular carrier for 5-fluoruracil: Synthesis, characterization and drug delivery evaluation / Muzzalupo, Rita; NICOLETTA Fiore Pasquale, ; Trombino, Sonia; Cassano, Roberta; Iemma, Francesca; Picci, N.. - In: COLLOIDS AND SURFACES. B, BIOINTERFACES. - ISSN 0927-7765. - 58(2007), pp. 197-202. |
| Handle: | http://hdl.handle.net/20.500.11770/123185 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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