In this study we have reported that bergapten (B) and bergapten plus UV (PUVA) are able to significantly affect MCF-7, ZR-75 and SKBR-3 breast cancer cell proliferations. B induced a lowering of PI3K/AKT survival signal in MCF-7 cells even in presence of IGF-I stimulation. Furthermore, B and in a higher extent, PUVA up-regulated the p53 mRNA and the protein content. An increased co-association between p21 WAF and proliferating cell nuclear antigen (PCNA) has been observed in PUVA-treated MCF-7 cells, thus inhibiting DNA replication. These results highlight how B, and its photoactivated compound, exert antiproliferative effects and induce apoptotic responses in breast cancer cells.
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|Titolo:||Breast cancer cell survival signal is affected by bergapten combined with an ultraviolet irradiation|
|Data di pubblicazione:||2010|
|Citazione:||Breast cancer cell survival signal is affected by bergapten combined with an ultraviolet irradiation / Panno, Maria Luisa; Giordano, Francesca; Mastroianni, F; Palma, Mg; Bartella, V; Carpino, A; Aquila, Saveria; Ando', Sebastiano. - In: FEBS LETTERS. - ISSN 0014-5793. - 584:11(2010), pp. 2321-2326.|
|Appare nelle tipologie:||1.1 Articolo in rivista|