p73, a member of the p53 family, is a transcription factor that plays a key role in many biological processes.In the present study, we show that TAp73 is expressed in neural stem cells (NSC) and its expressionincreases following their differentiation. NSC from p73 null mice have a reduced proliferativepotential, together with reduced expression of members of the Sox-2 and Notch gene families knownto be important for NSC proliferation. In parallel with this in vitro data, the width of the neurogenic areaswas reduced in the brains of embryonic and adult p73/ mice. These data suggest that p73, and in particularTAp73, is important for maintenance of the NSC pool.
p73 regulates maintenance of neural stem cell
Tucci P.;
2010-01-01
Abstract
p73, a member of the p53 family, is a transcription factor that plays a key role in many biological processes.In the present study, we show that TAp73 is expressed in neural stem cells (NSC) and its expressionincreases following their differentiation. NSC from p73 null mice have a reduced proliferativepotential, together with reduced expression of members of the Sox-2 and Notch gene families knownto be important for NSC proliferation. In parallel with this in vitro data, the width of the neurogenic areaswas reduced in the brains of embryonic and adult p73/ mice. These data suggest that p73, and in particularTAp73, is important for maintenance of the NSC pool.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
