Ferulic acid plays a chemopreventive role incancer by inducing tumor cells apoptosis. As mitochondriaplay a key role in the induction of apoptosis in many cellstypes, here we investigate the mitochondrial permeabilitytransition (MPT) and the release of cytochrome c inducedby ferulic acid and its esters in rat testes mitochondria, inTM-3 and MLTC-1 cells. While ferulic acid, but not itsesters, induced MPT and cytochrome c release in rat testesisolated mitochondria, in TM-3 cells we found that bothferulic acid and its esters induced cytochrome c releasefrom mitochondria in a dose-dependent manner, suggestinga potential target of these compounds in the induction ofcell apoptosis. The apoptosis induced by ferulic acid istherefore associated with the mitochondrial pathway involvingcytochrome c release and caspase-3 activation.

Synthesized esters of ferulic acid induce release of cytochrome c from rat testes mitochondria

Cione E.;Tucci P.;Trombino S.;Iemma F.;Picci N.;Genchi G.
2008-01-01

Abstract

Ferulic acid plays a chemopreventive role incancer by inducing tumor cells apoptosis. As mitochondriaplay a key role in the induction of apoptosis in many cellstypes, here we investigate the mitochondrial permeabilitytransition (MPT) and the release of cytochrome c inducedby ferulic acid and its esters in rat testes mitochondria, inTM-3 and MLTC-1 cells. While ferulic acid, but not itsesters, induced MPT and cytochrome c release in rat testesisolated mitochondria, in TM-3 cells we found that bothferulic acid and its esters induced cytochrome c releasefrom mitochondria in a dose-dependent manner, suggestinga potential target of these compounds in the induction ofcell apoptosis. The apoptosis induced by ferulic acid istherefore associated with the mitochondrial pathway involvingcytochrome c release and caspase-3 activation.
2008
ferulic acid, cytochrome c, apoptosis, mitochondria, TM-3 cells, MLTC-1 cells
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/123771
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 26
  • ???jsp.display-item.citation.isi??? 24
social impact