and rhizomes extracts and their constituents. The methanolic extract of rhizomes showedsignificant anti-inflammatory activity through inhibition of NO production in the murinemonocytic macrophage cell line RAW264.7. Among the isolated compounds, those which mosteffectively inhibited LPS-induced NO production were irisolidone and 7-methyl-tectorigenin-4′-O-[β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside], with IC50 values of 23.6 μM and29.4 μM respectively. Isoorientin and isovitexin exhibited the most promising activity againstAChE with IC50 of 26.8 μM and 36.4 μM, respectively. The same compounds exhibited also thehigher activity against BChE.
Protection against neurodegenerative diseases of Iris pseudopumila extracts and their constituents
CONFORTI, FILOMENA;LOIZZO, Monica Rosa;
2009-01-01
Abstract
and rhizomes extracts and their constituents. The methanolic extract of rhizomes showedsignificant anti-inflammatory activity through inhibition of NO production in the murinemonocytic macrophage cell line RAW264.7. Among the isolated compounds, those which mosteffectively inhibited LPS-induced NO production were irisolidone and 7-methyl-tectorigenin-4′-O-[β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside], with IC50 values of 23.6 μM and29.4 μM respectively. Isoorientin and isovitexin exhibited the most promising activity againstAChE with IC50 of 26.8 μM and 36.4 μM, respectively. The same compounds exhibited also thehigher activity against BChE.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
