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EnglishThis paper reports the feasibility to prepare a biodegradable material stable to gamma-irradiation by grafting of poly(lactide-co-glycolide) with pyrogallic acid (PLGA-g-PA) and ferulic acid (PLGA-g-FA) in mild condition. Only the grafting procedure with PA did not modify molecular weight (Mw) of the starting polymer and PLGA-g-PA showed antioxidant properties. The polymer degradation in pH 7.4 phosphate buffer saline (PBS) was mainly governed by a random chain scission mechanism according to a first-order reaction. The irradiation at the dose of 25 kGy caused only a very slight decrease of Mw and the degradation patterns of the non-irradiated and irradiated material were superimposable. PLGA-g-PA resulted a promising material to develop biodegradable drug delivery systems which would be sterilizable in the final container.
Pyrogallic acid-PLGA conjugate as new biodegradable material suitable for final sterilization by irradiation / Cilurzo, F; Puoci, Francesco; Selmin, F; Iemma, Francesca; Minghetti, P.. - In: POLYMERS FOR ADVANCED TECHNOLOGIES. - ISSN 1042-7147. - 22:12(2011), pp. 2201-2205.
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| Titolo: | Pyrogallic acid-PLGA conjugate as new biodegradable material suitable for final sterilization by irradiation |
| Autori: | |
| Data di pubblicazione: | 2011 |
| Rivista: | |
| Citazione: | Pyrogallic acid-PLGA conjugate as new biodegradable material suitable for final sterilization by irradiation / Cilurzo, F; Puoci, Francesco; Selmin, F; Iemma, Francesca; Minghetti, P.. - In: POLYMERS FOR ADVANCED TECHNOLOGIES. - ISSN 1042-7147. - 22:12(2011), pp. 2201-2205. |
| Handle: | http://hdl.handle.net/20.500.11770/125568 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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