A very simple approach to the enantioselective homologation of alpha-amino acids is presented which is based on the formation of N-Fmoc-aminoacyldiazomethanes with nearly quantitative yields and on the complete retention of both chiral configuration and N-terminal protecting group in the overall transformation. OI sindona, giovanni/0000-0002-5623-5795; Leggio, Antonella/0000-0002-4373-6232; Liguori, Angelo/0000-0003-4483-2506
A very simple approach to the enantioselective homologation of α-amino acids is presented which is based on the formation of N-Fmoc-aminoacyldiazomethanes with nearly quantitative yields and on the complete retention of both chiral configuration and N-terminal protecting group in the overall transformation.
Convenient and stereospecific homologation of N-Fluorenylmethoxycarbonyl-α-aminoacids to their β-homologues
LEGGIO, Antonella;Liguori A;SINDONA, Giovanni
1997-01-01
Abstract
A very simple approach to the enantioselective homologation of α-amino acids is presented which is based on the formation of N-Fmoc-aminoacyldiazomethanes with nearly quantitative yields and on the complete retention of both chiral configuration and N-terminal protecting group in the overall transformation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
