Standard Potential and Acidic Constants of Oleuropein

The standard potential of oleuropein, OleO(2)H(2), has been determined by a potentiometric titration method in 0.1 mol.dm(-3) NaClO(4) aqueous solutions employing a platinum wire-net working electrode. Oleuropein, the active ingredient present in food integrators extracted from olive leaves, in table olives, and in extra virgin olive oils, is a nutraceutical compound whose health benefits have been widely documented. For this reason, in our continuing investigation of metals with biological ligands, the acidic constants of oleuropein K(1) (OleO(2)H(2) reversible arrow H(+) + OleO(2)H(-)) and K(2) (Ole(O(2)H)(-) reversible arrow H(+) + OleO(2)(2-)) were determined for use in further studies of the complexing power of this ligand toward metals of biological interest. OI sindona, giovanni/0000-0002-5623-5795