The one-pot reduction of α-alkyl-β-ketonitriles to anti γ-amino alcohols can be efficiently performed by borane/dimethyl sulfide complex in the presence of cerium chloride as Lewis acid. Selectivities are slightly worse than monoreduction but this drawback is overcome by much better yields.
Stereoselective Complete Reduction of alpha-Alkyl-beta-ketonitriles to anti gamma-Amino Alcohols
De Nino A;DALPOZZO, Renato;MAIUOLO, Loredana;TAGARELLI, Antonio
2002-01-01
Abstract
The one-pot reduction of α-alkyl-β-ketonitriles to anti γ-amino alcohols can be efficiently performed by borane/dimethyl sulfide complex in the presence of cerium chloride as Lewis acid. Selectivities are slightly worse than monoreduction but this drawback is overcome by much better yields.File in questo prodotto:
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