Sufficient uteroplacental blood flow is essential for normal pregnancy outcome and is accomplished by the coordinated growth and remodelling of the entire maternal uterine vasculature. The main focus of this MiniReview is to provide information on upstream (pre-placental) maternal uterine vascular remodelling that facilitates gestational increases in uterine blood flow. Consideration of the three-dimensional pattern of remodelling (circumferential enlargement versus axial elongation), changes in vessel biomechanical properties, and underlying mechanisms [shear stress, nitric oxide, vascular endothelial growth factor (VEGF)/placental growth factor (PlGF), the renin-angiotensin system] and pathways (local versus systemic; venoarterial exchange) are provided using the rat as the principal animal model, although findings from other species are incorporated wherever possible to provide a comparative perspective. The process of maternal gestational uterine vascular remodelling involves a number of cellular processes and mechanisms, including trophoblast invasion, hyperplasia and hypertrophy, and changes in extracellular matrix composition. In addition, changes in cellular function, e.g. the secretory and contractile properties of smooth muscle and an up-regulation of endothelial vasodilatory influences may contribute to uteroplacental blood flow increases through changes in tone as well as in structure. Future studies aimed at better understanding the inter-relationship between changes in vessel structure (remodelling) and function (reactivity) would likely generate new mechanistic insights into the fascinating process of maternal gestational uterine vascular adaptation and provide a more physiological perspective of the underlying cellular processes involved in its regulation.
Physiological Remodelling of the Maternal Uterine Circulation during Pregnancy / Mandala', Maurizio; Osol, G.. - In: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. - ISSN 1742-7843. - 110:1(2012), pp. 12-18.
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|Titolo:||Physiological Remodelling of the Maternal Uterine Circulation during Pregnancy|
|Data di pubblicazione:||2012|
|Citazione:||Physiological Remodelling of the Maternal Uterine Circulation during Pregnancy / Mandala', Maurizio; Osol, G.. - In: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. - ISSN 1742-7843. - 110:1(2012), pp. 12-18.|
|Appare nelle tipologie:||1.1 Articolo in rivista|