In order to obtain rigidity within the sugar moiety of nucleosides, the bicyclic pyrimidine derivatives of N,O-isoxazolidines were designed and synthesized by using 1,3-dipolar cycloaddition of Δ1-pyrrolidine-1-oxide and the appropriate vinyl-nucleobases.
In order to obtain rigidity within the sugar moiety of nucleosides, the bicyclic pyrimidine derivatives of N,O-isoxazolidines were designed and synthesized by using 1,3-dipolar cycloaddition of Delta(1)-pyrrolidine-1-oxide and the appropriate vinyl-nucleobases. (C) 2004 Elsevier Ltd. All rights reserved. OI sindona, giovanni/0000-0002-5623-5795; ORTUSO, Francesco/0000-0001-6235-8161; ALCARO, Stefano/0000-0002-0437-358X
New conformationally locked bicyclic N,O-nucleoside analogues of antiviral drugs
DE NINO, Antonio;MAIUOLO, Loredana;SINDONA, Giovanni
2005-01-01
Abstract
In order to obtain rigidity within the sugar moiety of nucleosides, the bicyclic pyrimidine derivatives of N,O-isoxazolidines were designed and synthesized by using 1,3-dipolar cycloaddition of Δ1-pyrrolidine-1-oxide and the appropriate vinyl-nucleobases.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
