A convenient, recyclable catalytic synthesis of benzofuran-2-acetic esters 2 by sequential Pd(0)-catalyzeddeallylationdPd(II)-catalyzed carbonylative heterocyclization of 1-(2-allyloxyphenyl)-2-yn-1-ols 1 inionic liquids is presented. Reactions were typically carried out in BmimBF4 as the solvent at 100 C andunder 30 atm of CO, in the presence of catalytic amounts (1 mol %) of PdI2 in conjunction with KI(1 equiv), PPh3 (4 mol %), MeOH (28 equiv), and H2O (2 equiv). The solvent-catalyst system could berecycled several times without appreciable loss of catalytic activity
Tandem catalysis in ionic liquids: a recyclable catalytic synthesis of benzofuran derivatives
GABRIELE, Bartolo;MANCUSO R;VELTRI, Lucia
2010-01-01
Abstract
A convenient, recyclable catalytic synthesis of benzofuran-2-acetic esters 2 by sequential Pd(0)-catalyzeddeallylationdPd(II)-catalyzed carbonylative heterocyclization of 1-(2-allyloxyphenyl)-2-yn-1-ols 1 inionic liquids is presented. Reactions were typically carried out in BmimBF4 as the solvent at 100 C andunder 30 atm of CO, in the presence of catalytic amounts (1 mol %) of PdI2 in conjunction with KI(1 equiv), PPh3 (4 mol %), MeOH (28 equiv), and H2O (2 equiv). The solvent-catalyst system could berecycled several times without appreciable loss of catalytic activityFile in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
