Tween surfactants possess very interesting properties such as biodegradability, biocompatibility, and low toxicity.The synthesis of acrylate monomers by means of the chemical modification of polysorbate surfactants Tween 20, 40,and 60 with unsaturated groups is described. Monomers were obtained as a result of the reaction of methacrylicanhydride with different grades of Tween surfactants. Further polymerization was carried out in tetrahydrofuran,dimethylformamide, and a mixture of water-tetrahydrofuran. Physicochemistry properties of the polymer networkswere investigated, and the obtained results reveal that they strongly depend on the type of solvent used during thepolymerization, as well as on the concentration of the casting solution. In particular, our study demonstrated that,depending on the solvent boiling point, i.e., the facility to remove the solvent from the polymer matrix, it is possibleto predict properties of the network morphology. Moreover, in vitro studies on controlled release were accomplishedto demonstrate the possibility of utilizing these new materials as drug delivery systems. All resulting networks representa novel class of cross-linked polymeric materials useful both in pharmaceutical and chemical applications.
Synthesis and properties of methacrylic functionalized Tween monomer networks
Muzzalupo R.;Cassano R.;Trombino S.;Picci N.
2009-01-01
Abstract
Tween surfactants possess very interesting properties such as biodegradability, biocompatibility, and low toxicity.The synthesis of acrylate monomers by means of the chemical modification of polysorbate surfactants Tween 20, 40,and 60 with unsaturated groups is described. Monomers were obtained as a result of the reaction of methacrylicanhydride with different grades of Tween surfactants. Further polymerization was carried out in tetrahydrofuran,dimethylformamide, and a mixture of water-tetrahydrofuran. Physicochemistry properties of the polymer networkswere investigated, and the obtained results reveal that they strongly depend on the type of solvent used during thepolymerization, as well as on the concentration of the casting solution. In particular, our study demonstrated that,depending on the solvent boiling point, i.e., the facility to remove the solvent from the polymer matrix, it is possibleto predict properties of the network morphology. Moreover, in vitro studies on controlled release were accomplishedto demonstrate the possibility of utilizing these new materials as drug delivery systems. All resulting networks representa novel class of cross-linked polymeric materials useful both in pharmaceutical and chemical applications.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
