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EnglishThe chemical composition of the essential oils of Laurus nobilis, Juniperus oxycedrus ssp. oxycedrus,Thuja orientalis, Cupressus sempervirens ssp. pyramidalis, Pistacia palaestina, Salvia officinalis, andSatureja thymbra was determined by GC/MS analysis. Essential oils have been evaluated for theirinhibitory activity against SARS-CoV and HSV-1 replication in vitro by visually scoring of the virus inducedcytopathogenic effect post-infection. L. nobilis oil exerted an interesting activity against SARSCoVwith an IC50 value of 120 microg/ml and a selectivity index (SI) of 4.16. This oil was characterized by thepresence of beta-ocimene, 1,8-cineole, alpha-pinene, and beta-pinene as the main constituents. J. oxycedrus ssp.oxycedrus oil, in which alpha-pinene and beta-myrcene were the major constituents, revealed antiviral activityagainst HSV-1 with an IC50 value of 200 microg/ml and a SI of 5.
The chemical composition of the essential oils of Laurus nobilis, Juniperus oxycedrus ssp. oxycedrus,Thuja orientalis, Cupressus sempervirens ssp. pyramidalis, Pistacia palaestina, Salvia officinalis, andSatureja thymbra was determined by GC/MS analysis. Essential oils have been evaluated for theirinhibitory activity against SARS-CoV and HSV-1 replication in vitro by visually scoring of the virusinducedcytopathogenic effect post-infection. L. nobilis oil exerted an interesting activity against SARSCoVwith an IC50 value of 120 mg/ml and a selectivity index (SI) of 4.16. This oil was characterized by thepresence of b-ocimene, 1,8-cineole, a-pinene, and b-pinene as the main constituents. J. oxycedrus ssp.oxycedrus oil, in which a-pinene and b-myrcene were the major constituents, revealed antiviral activityagainst HSV-1 with an IC50 value of 200 mg/ml and a SI of 5.
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| Titolo: | Phytochemical analysis and in vitro antiviral activities of the essential oils of seven Lebanon species |
| Autori: | |
| Data di pubblicazione: | 2008 |
| Rivista: | |
| Handle: | http://hdl.handle.net/20.500.11770/130043 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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http://hdl.handle.net/20.500.11770/130043
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