The present study showed for the first time the in vitro properties (antioxidant, hypoglycaemic and anticholinesterase)of Citrus medica L. cv. Diamante which belongs to the Rutaceae family. The n-hexaneextract of Diamante citron peel is characterized by the presence of monoterpenes and sesquiterpenes.The most abundant constituents were two monoterpenes: limonene and γ -terpinene. The extract showedsignificant antioxidant activity that was carried out using different assays (DPPH test, β -carotene bleachingtest and bovine brain peroxidation assay). Oxidative damage, caused by the action of free radicals, mayinitiate and promote the progression of a number of chronic diseases, including diabetes and Alzheimer’sdisease. Diamante citron peel extract showed hypoglycaemic activity and an anticholinesterase effect.

In vitro activities of Citrus medica L. cv. Diamante (Diamante citron) relevant to treatment of Diabetes and Alzheimer's disease

CONFORTI, FILOMENA;TUNDIS, ROSA;LOIZZO, Monica Rosa;STATTI, Giancarlo;
2007-01-01

Abstract

The present study showed for the first time the in vitro properties (antioxidant, hypoglycaemic and anticholinesterase)of Citrus medica L. cv. Diamante which belongs to the Rutaceae family. The n-hexaneextract of Diamante citron peel is characterized by the presence of monoterpenes and sesquiterpenes.The most abundant constituents were two monoterpenes: limonene and γ -terpinene. The extract showedsignificant antioxidant activity that was carried out using different assays (DPPH test, β -carotene bleachingtest and bovine brain peroxidation assay). Oxidative damage, caused by the action of free radicals, mayinitiate and promote the progression of a number of chronic diseases, including diabetes and Alzheimer’sdisease. Diamante citron peel extract showed hypoglycaemic activity and an anticholinesterase effect.
2007
Citrus medica; Hypoglicaemic; Antioxidant
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/131178
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