In our screening program for antihypertensive properties of plants, the leaves of Ailanthus excelsa (Roxb), aplant used in Egyptian traditional medicine, were analysed. Chromatographic separation of A. excelsa MeOHextract yielded six flavonoids for the first time from this species, namely apigenin, luteolin, kaempferol-3-O-α-arabinopyranoside, kaempferol-3-O-β-galactopyranoside, quercetin-3-O-α-arabinopyranoside and luteolin-7-O-β-glucopyranoside. The in vitro hypotensive activities of the MeOH extract and the isolated compoundswere elucidated. All the flavonoids tested exhibited ACE inhibitory activity, in particular the most activecompound was kaempferol-3-O-β-galactopyranoside with an IC50 value of 260 μM.
Inhibition of Angiotensin Converting Enzyme (ACE) by Flavonoids isolated from Ailanthus excelsa (Roxb) (Simaroubaceae)
LOIZZO, Monica Rosa;TUNDIS, ROSA;STATTI, Giancarlo;
2007-01-01
Abstract
In our screening program for antihypertensive properties of plants, the leaves of Ailanthus excelsa (Roxb), aplant used in Egyptian traditional medicine, were analysed. Chromatographic separation of A. excelsa MeOHextract yielded six flavonoids for the first time from this species, namely apigenin, luteolin, kaempferol-3-O-α-arabinopyranoside, kaempferol-3-O-β-galactopyranoside, quercetin-3-O-α-arabinopyranoside and luteolin-7-O-β-glucopyranoside. The in vitro hypotensive activities of the MeOH extract and the isolated compoundswere elucidated. All the flavonoids tested exhibited ACE inhibitory activity, in particular the most activecompound was kaempferol-3-O-β-galactopyranoside with an IC50 value of 260 μM.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
