Caloric restriction, that is limiting food intake, is recognized in mammals as the best characterized and mostreproducible strategy for extending lifespan, retarding physiological aging and delaying the onset of age‐associated diseases.The aim of this mini review is to argue that p53 is the connection in the abilities of both the Sirt‐1 pathway and the TORpathway to impact on longevity of cells and organisms. This novel, lifespan regulating function of p53 may be evolutionarilymore ancient than its relatively recent role in apoptosis and tumour suppression, and is likely to provide many new insightsinto lifespan modulation.
Caloric restriction: is mammalian life extension linked to p53?
Tucci P.
2012-01-01
Abstract
Caloric restriction, that is limiting food intake, is recognized in mammals as the best characterized and mostreproducible strategy for extending lifespan, retarding physiological aging and delaying the onset of age‐associated diseases.The aim of this mini review is to argue that p53 is the connection in the abilities of both the Sirt‐1 pathway and the TORpathway to impact on longevity of cells and organisms. This novel, lifespan regulating function of p53 may be evolutionarilymore ancient than its relatively recent role in apoptosis and tumour suppression, and is likely to provide many new insightsinto lifespan modulation.File in questo prodotto:
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