Themechanismsbywhichinflammationaffectsthe different emotional moods are only partially known. Previous works have pointed to stress hormones like glucocorticoids plus the vascular factor endothelin-1 as key factors evoking stressful states especially in relation to endothelial dysfunctions. With this work, it was our intention to establish the role of pro- and anti-inflammatory cytokine expression variations towards depression-like behaviors and consequently the developmentofneurodegenerationeventscausedbyendothelial damages in the hamster (Mesocricetus auratus). Such a rodent, which is considered a valuable animal model to test depression and anxiety states, exhibited a variety of depression-like behaviors including reduction in sucrose consumption, locomotion, and exploration (p < 0.01) following exposure to unpredictable chronic mild stress. Contextually, a tight correlation between unpredictable chronic mild stressinduced depressive states and expression of the proinflammatory cytokines was detected as shown by marked expression levels (p < 0.01) of IL-1β and NF-kB in the hippocampus, amygdala, and prefrontal cortex. Even the antiinflammatory cytokine IL-10 supplied notably significant (p < 0.001) expression levels in the same areas of resilienthamsters. Application of hemodynamic and endothelial functionalstudiespointedtoalteredarterialendothelialactivitiesin depressed withrespect to resilient animals.Moreover, evident damagedneuronalfieldsintheaboveareasofdepressedhamstersallowedustocorrelatesuchabehavioralphenomenonto the upregulation of IL-1β and NF-κB. Overall, the differing roles of pro- and anti-inflammatory cytokines on depressive states, especially in view of brain endothelial damages, may provide novel therapeutic measures against mood disorders linked to neurodegenerative diseases.
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|Titolo:||Unpredictable chronic Mild stress paradigm established effect of pro- and anti-inflammatory cytokine on neurodegeneration-linked depressive states in Hamsters with Brain endothelial damages|
|Data di pubblicazione:||2017|
|Appare nelle tipologie:||1.1 Articolo in rivista|