An intense cross talk between mitochondria and nucleus continuously informs thecell about the functional state of these crucial organelles and elicits aneffective stress response that strenghtens the cell, promoting its survival.Interestingly, this effect can spread also in a non-cell autonomous fashion todistal tissues by means of soluble factors. This stress response is responsibleof a consistent lifespan increase in many animal models, while in humans there isstill a lack of knowledge. This review summarises the available data on theinvolvement of mitochondria in longevity focusing in particular on thissignalling activity and the consequent stress response that is elicited, andproposes the idea that, similarly to animal models, humans may benefit from this response in terms of delayed aging and longevity.

Mitochondria and mitochondria-induced signalling molecules as longevity determinants.

ROSE, Giuseppina;
2017-01-01

Abstract

An intense cross talk between mitochondria and nucleus continuously informs thecell about the functional state of these crucial organelles and elicits aneffective stress response that strenghtens the cell, promoting its survival.Interestingly, this effect can spread also in a non-cell autonomous fashion todistal tissues by means of soluble factors. This stress response is responsibleof a consistent lifespan increase in many animal models, while in humans there isstill a lack of knowledge. This review summarises the available data on theinvolvement of mitochondria in longevity focusing in particular on thissignalling activity and the consequent stress response that is elicited, andproposes the idea that, similarly to animal models, humans may benefit from this response in terms of delayed aging and longevity.
Mitochondria ; Mitochondrial uncoupling; Human longevity ; Mitokines ; Mitochondrial epigenetics
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/132058
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