Aim of the study: In recent years the use of medicinal plants has been growing worldwide and this isparticularly true in Lebanon. In the present investigationwe report the inhibitory activity against digestiveenzymes related to diabetes and angiotensin converting enzyme (ACE) of extracts of nine plant speciescollected in Lebanon, where they have a traditional use against diabetes.Materials and methods: In order to evaluate if the extraction procedure could influence the activity wedecided to perform different extractions with methanol, n-hexane and chloroform of Calamintha origanifolia,Satureja thymbra, Prangos asperula, Sideritis perfoliata, Asperula glomerata, Hyssopus officinalis,Erythraea centaurium, Marrubium radiatum and Salvia acetabulosa and test each of them.Results and conclusions: Marrubium radiatum and Salvia acetabulosa methanol extracts exerted the highestactivity against alpha-amylase (IC50 61.1 and 91.2 microg/ml, respectively) and alpha-glucosidase (IC50 68.8 and76.9 microg/ml, respectively). The same extracts exhibited a strong inhibitory activity against ACE with IC50 of72.7 and 52.7 microg/ml, respectively. The results support the traditional use of some the species examined.
In vitro inhibitory activities of plants used in Lebanon traditional medicine against angiotensin converting enzyme (ACE) and digestive enzymes related to diabetes
LOIZZO, Monica Rosa;TUNDIS, ROSA;Bonesi M;Statti GA;
2008-01-01
Abstract
Aim of the study: In recent years the use of medicinal plants has been growing worldwide and this isparticularly true in Lebanon. In the present investigationwe report the inhibitory activity against digestiveenzymes related to diabetes and angiotensin converting enzyme (ACE) of extracts of nine plant speciescollected in Lebanon, where they have a traditional use against diabetes.Materials and methods: In order to evaluate if the extraction procedure could influence the activity wedecided to perform different extractions with methanol, n-hexane and chloroform of Calamintha origanifolia,Satureja thymbra, Prangos asperula, Sideritis perfoliata, Asperula glomerata, Hyssopus officinalis,Erythraea centaurium, Marrubium radiatum and Salvia acetabulosa and test each of them.Results and conclusions: Marrubium radiatum and Salvia acetabulosa methanol extracts exerted the highestactivity against alpha-amylase (IC50 61.1 and 91.2 microg/ml, respectively) and alpha-glucosidase (IC50 68.8 and76.9 microg/ml, respectively). The same extracts exhibited a strong inhibitory activity against ACE with IC50 of72.7 and 52.7 microg/ml, respectively. The results support the traditional use of some the species examined.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
