CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishImpaired adult neurogenesis has been observed in several neurodegenerative diseases, including human immunodeficiency virus (HIV-1)-associated dementia (HAD). Here we report that the HIV-envelope glycoprotein gp120, which is associated with HAD pathogenesis, inhibits proliferation of adult neural progenitor cells (aNPCs) in vitro and in vivo in the dentate gyrus of the hippocampus of HIV/gp120-transgenic mice. We demonstrate that HIV/gp120 arrests cell-cycle progression of aNPCs at the G1 phase via a cascade consisting of p38 mitogen-activated protein kinase (MAPK) --> MAPK-activated protein kinase 2 (a cell-cycle checkpoint kinase) --> Cdc25B/C. Our findings define a molecular mechanism that compromises adult neurogenesis in this neurodegenerative disorder.
HIV/gp120 decreases adult neural progenitor cell proliferation via checkpoint kinase-mediated cell-cycle withdrawal and G1 arrest. / Okamoto, S; Kang, Yj; Brechtel, Cw; Siviglia, E; Russo, Rossella; Clemente, A; Harrop, A; Mckercher, S; Kaul, M; Lipton, Sa. - In: CELL STEM CELL. - ISSN 1934-5909. - 1:2(2007), pp. 230-236.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
| Titolo: | HIV/gp120 decreases adult neural progenitor cell proliferation via checkpoint kinase-mediated cell-cycle withdrawal and G1 arrest. | |
| Autori: | ||
| Data di pubblicazione: | 2007 | |
| Rivista: | ||
| Citazione: | HIV/gp120 decreases adult neural progenitor cell proliferation via checkpoint kinase-mediated cell-cycle withdrawal and G1 arrest. / Okamoto, S; Kang, Yj; Brechtel, Cw; Siviglia, E; Russo, Rossella; Clemente, A; Harrop, A; Mckercher, S; Kaul, M; Lipton, Sa. - In: CELL STEM CELL. - ISSN 1934-5909. - 1:2(2007), pp. 230-236. | |
| Handle: | http://hdl.handle.net/20.500.11770/132251 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
Copyright © 2021