Time-courses of both 'total' (unchanged plus metabolized) and unmetabolized acetaminophen were investigated in plasma and ocular tissues of rabbit after intravenous administration. The drug freely diffuses across the haemato-ocular barriers, reaching eye levels equal to those in the plasma; ocular concentrations are higher than those of all other investigated drugs. The time-course in aqueous is superimposable to that observed in the plasma; in other ocular tissues it is much slower. There is evidence of an ocular metabolism or a concentration into the eye of minor metabolites formed elsewhere.

Ocular disposition of acetaminophen and its metabolites following intravenous administration in rabbits. / Romanelli, L; Valeri, P; Morrone, Luigi Antonio; Pimpinella, G.. - In: JOURNAL OF OCULAR PHARMACOLOGY. - ISSN 8756-3320. - 7:4(1991), pp. 339.-350.

Ocular disposition of acetaminophen and its metabolites following intravenous administration in rabbits.

MORRONE, Luigi Antonio;
1991

Abstract

Time-courses of both 'total' (unchanged plus metabolized) and unmetabolized acetaminophen were investigated in plasma and ocular tissues of rabbit after intravenous administration. The drug freely diffuses across the haemato-ocular barriers, reaching eye levels equal to those in the plasma; ocular concentrations are higher than those of all other investigated drugs. The time-course in aqueous is superimposable to that observed in the plasma; in other ocular tissues it is much slower. There is evidence of an ocular metabolism or a concentration into the eye of minor metabolites formed elsewhere.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11770/135860
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