Disubstituted oxindoles represent an important family of bioactive compounds and synthetic derivatives that mimicry natural products. The construction of the asymmetric quaternary carbon at C-3 or C-2 is therefore a challenging problem for organic chemists. In the last years, many papers have appeared on asymmetric catalytic methods for the synthesis of these compounds, in particular about spirocyclic derivatives and this literature has been largely reviewed, as well as the literature on 3-substituted-3-hydroxyoxindoles and 3-substituted-3-aminooxindoles. On the other hand, literature on non-spirocyclic 3,3-dialkyloxindoles as well as on 2,2-disubtituted 3-indolinones has not fully reviewed, since our previous review on this topic to now. This review aims to fill this gap covering the literature on these topics

Recent Catalytic Asymmetric Synthesis of 3,3-Disubstituted Indolin-2-ones and 2,2-Disubstituted Indolin-3-one

DALPOZZO, Renato
2017

Abstract

Disubstituted oxindoles represent an important family of bioactive compounds and synthetic derivatives that mimicry natural products. The construction of the asymmetric quaternary carbon at C-3 or C-2 is therefore a challenging problem for organic chemists. In the last years, many papers have appeared on asymmetric catalytic methods for the synthesis of these compounds, in particular about spirocyclic derivatives and this literature has been largely reviewed, as well as the literature on 3-substituted-3-hydroxyoxindoles and 3-substituted-3-aminooxindoles. On the other hand, literature on non-spirocyclic 3,3-dialkyloxindoles as well as on 2,2-disubtituted 3-indolinones has not fully reviewed, since our previous review on this topic to now. This review aims to fill this gap covering the literature on these topics
asymmetric synthesis; oxindole; natural products
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11770/136051
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