Effect of the alteration of gonadal feed-back on LH and FSH release in man

To observe the influence of gonadal feed-back on FSH and LH release in men we studied the blood levels of both gonadotropins before and after orchiectomy in eight subjects. In four orchiectomized subjects the LH and FSH release induced by LH-RH was also studied. The LH-RH was also administered in eight patients with primary gonadal diseases. Our findings clearly show that FSH is more increased than LH by orchiectomy. The LH-RH administration in our subjects increased the FSH and LH similarly. These findings suggest that the specificity of pituitary responsiveness to LH-RH is under the influence of gonadal steroids.