A rapid and convenient large-scale strategy for the synthesis of some new isoxazolidinyl nucleosides, as potential antiviral drugs, is reported. In particular, a multistep methodology based either on the 1,3-dipolar cycloaddition approach or on a slight modification of the convertible nucleoside concept was exploited in the preparation of 4'-aza-2',3'-dideoxynucleoside, analogues containing cytosine and 5-methyl-cytosine. (C) 2001 Elsevier Science Ltd. All rights reserved.
Simple and efficient routes for the preparation of isoxazolidinyl nucleosides containing cytosine and 5-methylcytosine as new potential anti-HIV drugs
LIGUORI, Angelo;NAPOLI, Anna Maria Carmela Natale V;SICILIANO, Carlo;SINDONA, Giovanni
2001-01-01
Abstract
A rapid and convenient large-scale strategy for the synthesis of some new isoxazolidinyl nucleosides, as potential antiviral drugs, is reported. In particular, a multistep methodology based either on the 1,3-dipolar cycloaddition approach or on a slight modification of the convertible nucleoside concept was exploited in the preparation of 4'-aza-2',3'-dideoxynucleoside, analogues containing cytosine and 5-methyl-cytosine. (C) 2001 Elsevier Science Ltd. All rights reserved.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.