A rapid and convenient large-scale strategy for the synthesis of some new isoxazolidinyl nucleosides, as potential antiviral drugs, is reported. In particular, a multistep methodology based either on the 1,3-dipolar cycloaddition approach or on a slight modification of the convertible nucleoside concept was exploited in the preparation of 4'-aza-2',3'-dideoxynucleoside, analogues containing cytosine and 5-methyl-cytosine. (C) 2001 Elsevier Science Ltd. All rights reserved.

Simple and efficient routes for the preparation of isoxazolidinyl nucleosides containing cytosine and 5-methylcytosine as new potential anti-HIV drugs

LIGUORI, Angelo;NAPOLI, Anna Maria Carmela Natale V;SICILIANO, Carlo;SINDONA, Giovanni
2001-01-01

Abstract

A rapid and convenient large-scale strategy for the synthesis of some new isoxazolidinyl nucleosides, as potential antiviral drugs, is reported. In particular, a multistep methodology based either on the 1,3-dipolar cycloaddition approach or on a slight modification of the convertible nucleoside concept was exploited in the preparation of 4'-aza-2',3'-dideoxynucleoside, analogues containing cytosine and 5-methyl-cytosine. (C) 2001 Elsevier Science Ltd. All rights reserved.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/137573
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