Leptin, a pleiotropic molecule mainly produced by adipose tissue, was first discovered as a hormonecontrolling body weight and energy expenditure. In addition, leptin can modulate several processes inperipheral tissues such as immune response, fertility, hematopoiesis and carcinogenesis. The developmentof molecules that block or stimulate leptin receptor may therefore serve as a potent tool forstudying the role of leptin in mammalian physiology and pathology, but it also may open new possibilitiesfor therapy.This article presents an overview of current knowledge on leptin receptor modulators focusing onleptin mutein, leptin peptide modulators as well as small molecules with heterocyclic structure.
Therapeutic potential of leptin receptor modulators
Leggio A.;Catalano S.;De Marco R.;Barone I.;Andò S.;Liguori A.
2014-01-01
Abstract
Leptin, a pleiotropic molecule mainly produced by adipose tissue, was first discovered as a hormonecontrolling body weight and energy expenditure. In addition, leptin can modulate several processes inperipheral tissues such as immune response, fertility, hematopoiesis and carcinogenesis. The developmentof molecules that block or stimulate leptin receptor may therefore serve as a potent tool forstudying the role of leptin in mammalian physiology and pathology, but it also may open new possibilitiesfor therapy.This article presents an overview of current knowledge on leptin receptor modulators focusing onleptin mutein, leptin peptide modulators as well as small molecules with heterocyclic structure.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
