A novel synthesis of 2-ynamides (3) by palladium-catalyzed oxidative aminocarbonylation of alk-1-ynes (1) is reported. Reactions are catalyzed by PdI2:KI and are carried out at 100°C in dioxane as the solvent in the presence of dialkylamines (2) as nucleophiles (amine:alk-1-yne molar ratio1:1) using a 4:1 CO:air mixture (20 atm total pressure at 25°C).
A novel synthesis of 2-ynamides (3) by palladium-catalyzed oxidative aminocarbonylation of alk-1-ynes (1) is reported. Reactions are catalyzed by PdI2/KI and are carried out at 100 degreesC in dioxane as the solvent in the presence of dialkylamines (2) as nucleophiles (amine/alk-1-yne molar ratio = 1/1) using a 4/1 CO/air mixture (20 atm total pressure at 25 degreesC). (C) 2001 Elsevier Science B.V. All rights reserved.
SYNTHESIS OF 2-YNAMIDES BY DIRECT PALLADIUM-CATALYZED OXIDATIVE AMINOCARBONYLATION OF ALK-1-YNES
GABRIELE, Bartolo;VELTRI, Lucia;
2001-01-01
Abstract
A novel synthesis of 2-ynamides (3) by palladium-catalyzed oxidative aminocarbonylation of alk-1-ynes (1) is reported. Reactions are catalyzed by PdI2:KI and are carried out at 100°C in dioxane as the solvent in the presence of dialkylamines (2) as nucleophiles (amine:alk-1-yne molar ratio1:1) using a 4:1 CO:air mixture (20 atm total pressure at 25°C).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
