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EnglishThe dimethylsulfoxonium methylide is described as a unique and useful reagent for the simultaneous deprotection of amino and carboxyl function of N-Fmoc-alpha-amino acid and N-Fmoc-peptide esters. The new methodology was applied successfully both to solution- and solid-phase peptide synthesis. The adopted methodology was extended successfully also to peptides containing amino acids bearing acid-sensitive protecting group in side chains. Furthermore no measurable epimerization was observed in the deprotection reaction of N-Fmoc-dipeptide methyl esters with dimethylsulfoxonium methylide.
The dimethylsulfoxonium methylide as unique reagent for the simultaneous deprotection of amino and carboxyl function of N-Fmoc-alpha-amino acid and N-Fmoc- peptide esters / Spinella, M.; De Marco, R.; Belsito, E. L.; Leggio, A; Liguori, A.. - In: TETRAHEDRON. - ISSN 0040-4020. - 69(2013), pp. 2010-2016.
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| Titolo: | The dimethylsulfoxonium methylide as unique reagent for the simultaneous deprotection of amino and carboxyl function of N-Fmoc-alpha-amino acid and N-Fmoc- peptide esters |
| Autori: | LIGUORI, Angelo (Corresponding) |
| Data di pubblicazione: | 2013 |
| Rivista: | |
| Citazione: | The dimethylsulfoxonium methylide as unique reagent for the simultaneous deprotection of amino and carboxyl function of N-Fmoc-alpha-amino acid and N-Fmoc- peptide esters / Spinella, M.; De Marco, R.; Belsito, E. L.; Leggio, A; Liguori, A.. - In: TETRAHEDRON. - ISSN 0040-4020. - 69(2013), pp. 2010-2016. |
| Handle: | http://hdl.handle.net/20.500.11770/139584 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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