The dimethylsulfoxonium methylide is described as a unique and useful reagent for the simultaneous deprotection of amino and carboxyl function of N-Fmoc-alpha-amino acid and N-Fmoc-peptide esters. The new methodology was applied successfully both to solution- and solid-phase peptide synthesis. The adopted methodology was extended successfully also to peptides containing amino acids bearing acid-sensitive protecting group in side chains. Furthermore no measurable epimerization was observed in the deprotection reaction of N-Fmoc-dipeptide methyl esters with dimethylsulfoxonium methylide.
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|Titolo:||The dimethylsulfoxonium methylide as unique reagent for the simultaneous deprotection of amino and carboxyl function of N-Fmoc-alpha-amino acid and N-Fmoc- peptide esters|
LEGGIO, Antonella (Corresponding)
LIGUORI, Angelo (Corresponding)
|Data di pubblicazione:||2013|
|Appare nelle tipologie:||1.1 Articolo in rivista|