novel multicomponent cascade processis reported, based on the sequential combination betweenan initial nucleophilic attack step to an iminemoiety and a palladium-catalyzed oxidative heterocyclization-alkoxycarbonylation process. By this newprocess, five simple molecules [2-alkynylanilineimines, alcohol (ROH), carbon monoxide (CO), alcohol(ROH), and oxygen (O2)] are sequentially activated,selectively leading to high value-added functionalizedindole derivatives in a single operation.
Multicomponent Cascade Reactions: A Novel and Expedient Approach to Functionalized Indoles by an Unprecedented Nucleophilic Addition-Heterocyclization-Oxidative Alkoxycarbonylation Sequence
GABRIELE, Bartolo;VELTRI, Lucia;MANCUSO R;
2010-01-01
Abstract
novel multicomponent cascade processis reported, based on the sequential combination betweenan initial nucleophilic attack step to an iminemoiety and a palladium-catalyzed oxidative heterocyclization-alkoxycarbonylation process. By this newprocess, five simple molecules [2-alkynylanilineimines, alcohol (ROH), carbon monoxide (CO), alcohol(ROH), and oxygen (O2)] are sequentially activated,selectively leading to high value-added functionalizedindole derivatives in a single operation.File in questo prodotto:
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