CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishThe position of the amino-oxo-imino-oxo tautomeric equilibrium of gaseous deoxycytidines is affected by the acylation of the exocyclic nitrogen atom of the nucleobase. AM1 quantum-mechanical calculations show that the imino-oxo tautomers are thermodynamically more stable and possess lower-lying lowest unoccupied molecular orbitals than the related amino-oxo isomers. Accordingly, ionization of the acylated derivatives 2-7 by fast atom bombardment produces stable M(-.) radical anions. The lowest critical-energy unimolecular dissociation of the (M-H)(-) species which corresponds to the elimination of isocyanate units, gave further insights into the existence of the gaseous deoxycytidines 2-7 in their imino-oxo form.
The position of the amino-oxo-imino-oxo tautomeric equilibrium of gaseous deoxycytidines is affected by the acylation of the exocyclic nitrogen atom of the nucleobase. AM1 quantum-mechanical calculations show that the imino-oxo tautomers are thermodynamically more stable and possess lower-lying lowest unoccupied molecular orbitals than the related amino-oxo isomers. Accordingly, ionization of the acylated derivatives 2-7 by fast atom bombardment produces stable M(-.) radical anions. The lowest critical-energy unimolecular dissociation of the (M-H)(-) species which corresponds to the elimination of isocyanate units, gave further insights into the existence of the gaseous deoxycytidines 2-7 in their imino-oxo form.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
| Titolo: | Probing of the tautomeric amino-oxo vs imino-oxo equilibrium of substituted deoxycytidines by fast atom bombardment mass spectrometry |
| Autori: | |
| Data di pubblicazione: | 1995 |
| Rivista: | |
| Abstract: | The position of the amino-oxo-imino-oxo tautomeric equilibrium of gaseous deoxycytidines is affected by the acylation of the exocyclic nitrogen atom of the nucleobase. AM1 quantum-mechanical calculations show that the imino-oxo tautomers are thermodynamically more stable and possess lower-lying lowest unoccupied molecular orbitals than the related amino-oxo isomers. Accordingly, ionization of the acylated derivatives 2-7 by fast atom bombardment produces stable M(-.) radical anions. The lowest critical-energy unimolecular dissociation of the (M-H)(-) species which corresponds to the elimination of isocyanate units, gave further insights into the existence of the gaseous deoxycytidines 2-7 in their imino-oxo form. |
| Handle: | http://hdl.handle.net/20.500.11770/141508 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/20.500.11770/141508
Copyright © 2021