In this work, molecularly imprinted nanospheres for controlled/sustained releaseof quercetin were synthesized employing methacrylic acid and ethylene glycoldymethacrylateas functional monomer and crosslinking agent, respectively. One pot precipitationpolymerization was chosen as polymerization technique to obtain nanosized materials withspherical shape. Morphological and hydrophilic properties by scanning electronmicroscopy and water content measurements were determined, and recognition andselectivity properties of the imprinted materials were tested using the template quercetinand its structural analogue, the flavonoid catechin. Finally, the applicability of the obtainedmaterials as drug delivery devices was evaluated by performing in vitro release studies inplasma simulating fluids and cytotoxicity testson HeLa cells.
Quercetin- Imprinted Nanospheres as Novel Drug Delivery Devices
Curcio M;Cirillo G;Parisi OI;IEMMA Francesca;PICCI Nevio;PUOCI Francesco
2012-01-01
Abstract
In this work, molecularly imprinted nanospheres for controlled/sustained releaseof quercetin were synthesized employing methacrylic acid and ethylene glycoldymethacrylateas functional monomer and crosslinking agent, respectively. One pot precipitationpolymerization was chosen as polymerization technique to obtain nanosized materials withspherical shape. Morphological and hydrophilic properties by scanning electronmicroscopy and water content measurements were determined, and recognition andselectivity properties of the imprinted materials were tested using the template quercetinand its structural analogue, the flavonoid catechin. Finally, the applicability of the obtainedmaterials as drug delivery devices was evaluated by performing in vitro release studies inplasma simulating fluids and cytotoxicity testson HeLa cells.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
