The aluminium trichloride/toluene system is investigated as a novel, unusual and straightforward reagent for the removal of the 9-fluorenylmethoxycarbonyl (Fmoc) protecting group in the solution peptide synthesis. This procedure avoids any undesired side reactions, such as the frequently observed inversion of the amino acid configuration.
The aluminium trichloride/toluene system is investigated as a novel, unusual and straightforward reagent for the removal of the 9- fluorenylmethoxycarbonyl (Fmoc) protecting group in the solution peptide synthesis. This procedure avoids any undesired side reactions, such as the frequently observed inversion of the amino acid configuration.
New strategies for an efficient removal of the 9-fluorenylmethoxycarbonyl (Fmoc) protecting group in the peptide synthesis
LEGGIO, Antonella;LIGUORI, Angelo;Napoli A;SICILIANO, Carlo;SINDONA, Giovanni
2000-01-01
Abstract
The aluminium trichloride/toluene system is investigated as a novel, unusual and straightforward reagent for the removal of the 9- fluorenylmethoxycarbonyl (Fmoc) protecting group in the solution peptide synthesis. This procedure avoids any undesired side reactions, such as the frequently observed inversion of the amino acid configuration.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
