A study of the methylation of N-nosyl-α-amino acids and derivatives with trimethylsilyldiazomethane is here reported. Trimethylsilyldiazomethane allows the chemo-specific methylation of the carboxyl function of N-nosyl-α-amino acids in high yields and purity. This method provides a practical route to N-methyl-α-amino acids avoiding the use of the more toxic and explosive diazomethane. This simple and safe methylation methodology of α-amino acids and derivatives is not limited to organic synthesis and involves the use of a commercially available reagent as well.
Methylation of alpha-amino acids and derivatives using trimethylsilyldiazomethane / Leggio, Antonella; Liguori, A; Perri, F; Siciliano, Carlo; Viscomi, M. C.. - In: CHEMICAL BIOLOGY & DRUG DESIGN. - ISSN 1747-0277. - 73(2009), pp. 287-291.
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Titolo: | Methylation of alpha-amino acids and derivatives using trimethylsilyldiazomethane |
Autori: | |
Data di pubblicazione: | 2009 |
Rivista: | |
Citazione: | Methylation of alpha-amino acids and derivatives using trimethylsilyldiazomethane / Leggio, Antonella; Liguori, A; Perri, F; Siciliano, Carlo; Viscomi, M. C.. - In: CHEMICAL BIOLOGY & DRUG DESIGN. - ISSN 1747-0277. - 73(2009), pp. 287-291. |
Handle: | http://hdl.handle.net/20.500.11770/142922 |
Appare nelle tipologie: | 1.1 Articolo in rivista |