A study of the methylation of N-nosyl-α-amino acids and derivatives with trimethylsilyldiazomethane is here reported. Trimethylsilyldiazomethane allows the chemo-specific methylation of the carboxyl function of N-nosyl-α-amino acids in high yields and purity. This method provides a practical route to N-methyl-α-amino acids avoiding the use of the more toxic and explosive diazomethane. This simple and safe methylation methodology of α-amino acids and derivatives is not limited to organic synthesis and involves the use of a commercially available reagent as well.

Methylation of alpha-amino acids and derivatives using trimethylsilyldiazomethane

LEGGIO, Antonella;SICILIANO, Carlo;
2009

Abstract

A study of the methylation of N-nosyl-α-amino acids and derivatives with trimethylsilyldiazomethane is here reported. Trimethylsilyldiazomethane allows the chemo-specific methylation of the carboxyl function of N-nosyl-α-amino acids in high yields and purity. This method provides a practical route to N-methyl-α-amino acids avoiding the use of the more toxic and explosive diazomethane. This simple and safe methylation methodology of α-amino acids and derivatives is not limited to organic synthesis and involves the use of a commercially available reagent as well.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/142922
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 6
social impact