Purpose: To analyze the surface optics of 4 currently available intraocular lenses (IOLs) with atomic force microscopy. Setting: Licryl Laboratory, University of Calabria, Rende, Italy. Methods: The surface roughness and topography of poly(methyl methacrylate) (PMMA), silicone, hydrophobic, and hydrophilic acrylic IOLs were evaluated with atomic force microscopy in contact mode. The analysis was performed in a liquid environment using cantilevers with a 0.01 Newtonw/meter nominal elastic constant. Measurements were made over areas of 10 μm2 on different locations of the posterior optic surface of the IOL. Results: Atomic force microscopy permitted high-resolution imaging of IOL optic surface characteristics. Surface topography showed different features with respect to the lens biomaterial. The root-mean-square roughness of the IOL optic surface was significantly different between lenses of various materials (P<.001). The hydrophobic acrylic and silicone IOLs had the lowest mean surface roughness, 3.8 nm ± 0.2 (SD) and 4.0 ± 0.5 nm, respectively, and the 2 PMMA IOLs had the highest mean surface roughness, 6.6 ± 0.3 nm and 7.0 ± 0.6 nm. Conclusions: Atomic force microscopy was effective and accurate in analyzing IOL optics. The surface topography of IOLs may vary with different manufacturing processes.

Analysis of intraocular lens surface properties with atomic force microscopy

DE SANTO, Maria Penelope;BARBERI, Riccardo Cristoforo;
2006-01-01

Abstract

Purpose: To analyze the surface optics of 4 currently available intraocular lenses (IOLs) with atomic force microscopy. Setting: Licryl Laboratory, University of Calabria, Rende, Italy. Methods: The surface roughness and topography of poly(methyl methacrylate) (PMMA), silicone, hydrophobic, and hydrophilic acrylic IOLs were evaluated with atomic force microscopy in contact mode. The analysis was performed in a liquid environment using cantilevers with a 0.01 Newtonw/meter nominal elastic constant. Measurements were made over areas of 10 μm2 on different locations of the posterior optic surface of the IOL. Results: Atomic force microscopy permitted high-resolution imaging of IOL optic surface characteristics. Surface topography showed different features with respect to the lens biomaterial. The root-mean-square roughness of the IOL optic surface was significantly different between lenses of various materials (P<.001). The hydrophobic acrylic and silicone IOLs had the lowest mean surface roughness, 3.8 nm ± 0.2 (SD) and 4.0 ± 0.5 nm, respectively, and the 2 PMMA IOLs had the highest mean surface roughness, 6.6 ± 0.3 nm and 7.0 ± 0.6 nm. Conclusions: Atomic force microscopy was effective and accurate in analyzing IOL optics. The surface topography of IOLs may vary with different manufacturing processes.
Intraocular Lenses; Atomic Force Microscopy; Surface properties; Acrylic Resins; Polymethyl Methacrylate; silicone elastomers
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/142974
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