The Sulforodamine B (SRB) assay was used to test cytotoxicity against four human cancercell lines and one normal cell line of antioxidant constituents isolated from Hypericumtriquetrifolium Turra. Methanolic extract and pure compounds were tested against the largecell lung carcinoma cell line COR-L23, the hepatocellular carcinoma cell line HepG-2, renalcell adenocarcinoma ACHN, the amelanotic melanoma cell line C32 and normal humanfoetal lung MRC5. The results showed that I3-II8-biapigenin exhibited strong cytotoxic activity(IC50¼5.73 mg/mL) showing a certain degree of selectivity against the different cell types.
Cytotoxic activity of antioxidant constituents from Hypericum triquetrifolium Turra
CONFORTI, FILOMENA;LOIZZO, Monica Rosa;STATTI, Giancarlo;
2007-01-01
Abstract
The Sulforodamine B (SRB) assay was used to test cytotoxicity against four human cancercell lines and one normal cell line of antioxidant constituents isolated from Hypericumtriquetrifolium Turra. Methanolic extract and pure compounds were tested against the largecell lung carcinoma cell line COR-L23, the hepatocellular carcinoma cell line HepG-2, renalcell adenocarcinoma ACHN, the amelanotic melanoma cell line C32 and normal humanfoetal lung MRC5. The results showed that I3-II8-biapigenin exhibited strong cytotoxic activity(IC50¼5.73 mg/mL) showing a certain degree of selectivity against the different cell types.File in questo prodotto:
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