This study is aimed to evaluate the in vitro cytotoxicity of Senecio stabianusLacaita (Asteraceae) against renal adenocarcinoma ACHN, hormone-dependentprostate carcinoma LNCaP, amelanotic melanoma C32 and human breastadenocarcinoma MCF-7 cell lines. The n-hexane extract showed an interestingactivity with IC50 values of 62.7 and 71.1 microg/mL against C32 and LNCaP,respectively. Two compounds identified in the n-hexane extract, linalool andbeta-caryophyllene, were found to be active against C32 cells (IC50 values of 23.2and 20.1 microg/mL, respectively). Among tested constituents, the highest activity was found when alpha-humulene was applied to LNCaP cells (IC50 of 11.2 microg/mL).In order to complete the phytochemical study on S. stabianus, which has not beeninvestigated previously, the most characteristic secondary metabolites of Seneciogenus, pyrrolizidine alkaloids (PAs), were analysed. Here we report the isolation,structural elucidation and identification of nine PAs.
In vitro cytotoxic effects of Senecio stabianus Lacaita (Asteraceae) on human cancer cell lines
TUNDIS R.;MONICA R. LOIZZO;MARCO BONESI;STATTI G;NICODEMO G. PASSALACQUA;GIANCARLO STATTI;
2009-01-01
Abstract
This study is aimed to evaluate the in vitro cytotoxicity of Senecio stabianusLacaita (Asteraceae) against renal adenocarcinoma ACHN, hormone-dependentprostate carcinoma LNCaP, amelanotic melanoma C32 and human breastadenocarcinoma MCF-7 cell lines. The n-hexane extract showed an interestingactivity with IC50 values of 62.7 and 71.1 microg/mL against C32 and LNCaP,respectively. Two compounds identified in the n-hexane extract, linalool andbeta-caryophyllene, were found to be active against C32 cells (IC50 values of 23.2and 20.1 microg/mL, respectively). Among tested constituents, the highest activity was found when alpha-humulene was applied to LNCaP cells (IC50 of 11.2 microg/mL).In order to complete the phytochemical study on S. stabianus, which has not beeninvestigated previously, the most characteristic secondary metabolites of Seneciogenus, pyrrolizidine alkaloids (PAs), were analysed. Here we report the isolation,structural elucidation and identification of nine PAs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
